Neopentylamine → HCID 178446492, 화합물

HRID 1179680노트

반응식

HRID 1179680 반응식
[OH:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=O)=[CH:4][N:3]=1.ON1C2N=CC=CC=2N=N1.Cl.CN(C)CCCN=C=NCC.[CH3:33][C:34]([CH3:38])([CH3:37])[CH2:35][NH2:36].C(N(CC)C(C)C)(C)C>CN(C)C=O.C(OCC)(=O)C>[CH3:33][C:34]([CH3:38])([CH3:37])[CH2:35][NH:36][C:6](=[O:8])[C:5]1[CH:9]=[CH:10][C:2]([OH:1])=[N:3][CH:4]=1

참가 물질

8

반응물 5

HCID 79882NeopentylamineHCID 81531DiisopropylethylamineHCID 181649HOAtHCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 178418479HCID 178418479, 화합물

생성물 1

HCID 178446492HCID 178446492, 화합물

시약·촉매·용매 2

HCID 6228Dimethylformamide용매2회HCID 8857Ethyl Acetate용매

실험 절차

A solution of 6-hydroxynicotinic acid (1.39 g, 10.0 mmol), 1-hydroxy-7-azabenztriazole (1.50 g, 11.0 mmol), and 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (2.11 g, 11.0 mmol) in dimethylformamide (25 mL) was stirred at room temperature for 20 minutes. A solution of 2,2-dimethylpropylamine (0.96 g, 11.0 mmol) and N,N-diisopropylethylamine (1.42 g, 11.0 mmol) in a small amount of dimethylformamide was added. Stirring was continued for 0.5 hour at room temperature. Ethyl acetate was added and the reaction mixture was extracted twice with water. The solvent was evaporated in vacuo yielding the title compound, which was used without further purification.

후처리

  1. extractionthe reaction mixture was extracted twice with water
  2. customThe solvent was evaporated in vacuo

출처 및 근거

ORD 기록
ord-4d7fde8ce9b046089671aff8df6d3027
출처 데이터셋
uspto-grants-2007_10
특허 번호
US07279470B2

반응 노트

불러오는 중…