Phenol → 2-Bromo-6-phenoxypyridine

HRID 1183411노트

반응식

HRID 1183411 반응식
Br[C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Br:8])[N:3]=1.[C:9]1([OH:15])[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1.CC(C)([O-])C.[K+]>CS(C)=O>[Br:8][C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([O:15][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[N:3]=1

참가 물질

5

반응물 3

HCID 996PhenolHCID 122742,6-DibromopyridineHCID 23665647Potassium tert-butoxide

생성물 1

HCID 8245892-Bromo-6-phenoxypyridine

시약·촉매·용매 1

HCID 679Dimethyl Sulfoxide용매

반응 조건

온도
160 °C

실험 절차

2,6-Dibromo-pyridine (2 g, 8.44 mmol) and phenol (0.794 g, 8.44 mmol) were dissolved in DMSO (20 mL) and potassium tert-butoxide (0.947 g, 8.44 mmol) was added. The reaction was heated to 160° C. overnight then allowed to cool to room temperature. The reaction was submitted to aqueous workup and silica gel chromatography to afford the title compound.

후처리

  1. temperatureto cool to room temperature

출처 및 근거

ORD 기록
ord-bfe40919a67f45a39a9a6a44f42e9d2d
출처 데이터셋
uspto-grants-2014_03
특허 번호
US08664220B2

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