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Hydrochloric Acid → 4-((4-Methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)benzoic acid

HRID 1184848
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반응식

HRID 1184848 반응식
C([O:3][C:4](=[O:23])[C:5]1[CH:10]=[CH:9][C:8]([CH2:11][N:12]2[CH2:17][CH2:16][N:15]([CH3:18])[CH2:14][CH2:13]2)=[C:7]([C:19]([F:22])([F:21])[F:20])[CH:6]=1)C.[OH-].[Na+].Cl>C(O)C>[CH3:18][N:15]1[CH2:16][CH2:17][N:12]([CH2:11][C:8]2[CH:9]=[CH:10][C:5]([C:4]([OH:23])=[O:3])=[CH:6][C:7]=2[C:19]([F:22])([F:20])[F:21])[CH2:13][CH2:14]1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 23145917Ethyl 4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)benzoate

생성물 1

HCID 231458804-((4-Methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)benzoic acid수율 104%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To a solution of 4-(4-methyl-piperazin-1-ylmethyl)-3-trifluoromethyl-benzoic acid ethyl ester 37 (21 mg, 0.064 mmol) in ethanol (5 mL) was added 2N NaOH (0.318 mL, 0.636 mmol). The resulting mixture was stirred at rt for 2 h. The reaction mixture was acidified with 2N HCl solution and concentrated in vacuo to give the crude 4-(4-methyl-piperazin-1-ylmethyl)-3-trifluoromethyl-benzoic acid 38 (20 mg, 104%) which was used without further purification.

후처리

  1. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-0bf4be6a6b5e43209bb7393ed60a1c97
출처 데이터셋
uspto-grants-2014_03
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08669256B2

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