Hydrochloric Acid → 4-((((Benzyloxy)carbonyl)amino)methyl)benzoic acid

HRID 11862

반응식

HRID 11862 반응식
[NH2:1][CH2:2][C:3]1[CH:11]=[CH:10][C:6]([C:7]([OH:9])=[O:8])=[CH:5][CH:4]=1.[CH2:12]([O:19][C:20](Cl)=[O:21])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1.Cl>[OH-].[Na+]>[C:20]([NH:1][CH2:2][C:3]1[CH:4]=[CH:5][C:6]([C:7]([OH:9])=[O:8])=[CH:10][CH:11]=1)([O:19][CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)=[O:21]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 10387Benzyl chloroformateHCID 655264-(Aminomethyl)Benzoic Acid

생성물 1

HCID 14799974-((((Benzyloxy)carbonyl)amino)methyl)benzoic acid

시약·촉매·용매 1

HCID 14798Sodium Hydroxide용매2회

실험 절차

Commercially available 4-aminomethylbenzoic acid (5 g) was dissolved in 1 mol/l aqueous solution of sodium hydroxide (33 ml). Benzylchloroformate (5.2 ml) and 1 mol/l aqueous solution sodium hydroxide (40 ml) were gradually and simultaneously added while stirring at room temperature. After 3 hours, 1 mol/l hydrochloric acid was added to the reaction solution to adjust the pH to 3, and the deposited precipitate was collected by filtration through glass filter G4. The precipitate was washed with water and hexane, and dried under reduced pressure to obtain the title compound (8.162 g) as a white solid.

후처리

  1. additionsimultaneously added
  2. filtrationthe deposited precipitate was collected by filtration through glass
  3. filtrationfilter G4
  4. washThe precipitate was washed with water and hexane
  5. customdried under reduced pressure

출처 및 근거

ORD 기록
ord-4d0b5681f2aa4659be4d853e461c318f
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07098215B2

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