Oxalic Acid → 5-Trifluoromethyl-quinazoline-2,4-diamine

HRID 1186457노트

반응식

HRID 1186457 반응식
[N:1]1[CH:6]=[CH:5][C:4]([NH2:7])=[C:3]([NH2:8])[CH:2]=1.[C:9](O)(=[O:13])[C:10](O)=[O:11]>Cl>[NH:7]1[C:10](=[O:11])[C:9](=[O:13])[NH:8][C:3]2[CH:2]=[N:1][CH:6]=[CH:5][C:4]1=2

참가 물질

4

반응물 2

HCID 971Oxalic AcidHCID 59183,4-Diaminopyridine

생성물 1

HCID 107970835-Trifluoromethyl-quinazoline-2,4-diamine수율 107.2%

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매

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온도
100 °C

실험 절차

Pyridine-3,4-diamine (2.00 g, 18.3 mmol) and oxalic acid (1.96 g, 20.2 mmol) were dissolved in an aqueous hydrochloric acid solution (2.00 M, 20.0 mL) and the mixture was stirred with heat at 100° C. for 24 hours. After the reaction mixture was cooled to room temperature, the precipitate was collected by filtration and dried under reduced pressure. Thus, pyrido[3,4-b]pyrazine-2,3(1H,4H)-dione (3.20 g, 74%) was obtained.

후처리

  1. temperatureAfter the reaction mixture was cooled to room temperature
  2. filtrationthe precipitate was collected by filtration
  3. customdried under reduced pressure

출처 및 근거

ORD 기록
ord-ba671b75e81a4b0da17c094fb65b3474
출처 데이터셋
uspto-grants-2014_03
특허 번호
US08673908B2

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