Hydrochloric Acid → 2,6-Difluoro-3-nitrobenzoic acid

HRID 1187294노트

반응식

HRID 1187294 반응식
C([O:8][C:9](=[O:21])[C:10]1[C:15]([F:16])=[CH:14][CH:13]=[C:12]([N+:17]([O-:19])=[O:18])[C:11]=1[F:20])C1C=CC=CC=1.[OH-].[Na+].Cl>O1CCCC1.O>[F:20][C:11]1[C:12]([N+:17]([O-:19])=[O:18])=[CH:13][CH:14]=[C:15]([F:16])[C:10]=1[C:9]([OH:21])=[O:8]

참가 물질

6

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 583170052,6-Difluoro-3-nitro-benzoic acid benzyl ester

생성물 1

HCID 3026292,6-Difluoro-3-nitrobenzoic acid수율 56.8%

시약·촉매·용매 2

HCID 962Water용매HCID 8028Tetrahydrofuran용매

실험 절차

To 2,6-difluoro-3-nitro-benzoic acid benzyl ester (47, 750 mg, 2.6 mmol) in 4 mL of tetrahydrofuran and 2 mL of water, sodium hydroxide (0.2 g, 5.0 mmol) is added and the reaction is stirred for 2 hours. The reaction is acidified with dilute hydrochloric acid and extracted with ethyl acetate. The organic layer is concentrated under vacuum to provide the desired compound (48, 300 mg).

후처리

  1. extractionextracted with ethyl acetate
  2. concentrationThe organic layer is concentrated under vacuum

출처 및 근거

ORD 기록
ord-c579b3f9030948b38928ca0b846d3113
출처 데이터셋
uspto-grants-2014_03
특허 번호
US08673928B2

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