Nitrogen → 2-(3-Acetyl-pyrazol-1-ylmethyl)-oxazole-4-carboxylic acid

HRID 1189391노트

반응식

HRID 1189391 반응식
N#N.C([O:5][C:6]([C:8]1[N:9]=[C:10]([CH2:13][N:14]2[CH:18]=[CH:17][C:16]([C:19](=[O:21])[CH3:20])=[N:15]2)[O:11][CH:12]=1)=[O:7])C.[OH-].[Na+]>C1COCC1.Cl>[C:19]([C:16]1[CH:17]=[CH:18][N:14]([CH2:13][C:10]2[O:11][CH:12]=[C:8]([C:6]([OH:7])=[O:5])[N:9]=2)[N:15]=1)(=[O:21])[CH3:20]

참가 물질

6

반응물 3

HCID 947NitrogenHCID 14798Sodium HydroxideHCID 671284172-(3-Acetyl-pyrazol-1-ylmethyl)-oxazole-4-carboxylic acid ethyl ester

생성물 1

HCID 671287672-(3-Acetyl-pyrazol-1-ylmethyl)-oxazole-4-carboxylic acid

시약·촉매·용매 2

HCID 313Hydrochloric Acid용매HCID 8028Tetrahydrofuran용매

실험 절차

In a flame dried round-bottomed flask equipped with a magnetic stir bar and under inert atmosphere (N2), a solution of 2-(3-acetyl-pyrazol-1-ylmethyl)-oxazole-4-carboxylic acid ethyl ester (137 mg, 0.52 mmol) in THF (5.0 mL) was treated at rt with 1N NaOH (2.5 mL, 2.5 mmol) and the reaction mixture was stirred for 3 h at rt. The reaction mixture was poured in 1N HCl (23 mL) and extracted with EA (50 mL). The org. extracts were dried over MgSO4, filtered, and the solvent was removed under reduced pressure to give the crude 2-(3-acetyl-pyrazol-1-ylmethyl)-oxazole-4-carboxylic acid as a deep brown foam. LC-MS-conditions 02: tR=0.64 min, [M+H]+=236.13.

후처리

  1. extractionextracted with EA (50 mL)
  2. dry with materialextracts were dried over MgSO4
  3. filtrationfiltered
  4. customthe solvent was removed under reduced pressure

출처 및 근거

ORD 기록
ord-c845448f96bc494880a3c51bdb5455ab
출처 데이터셋
uspto-grants-2014_03
특허 번호
US08674111B2

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