Hydrochloric Acid → HCID 178482234, 화합물

HRID 1189640

반응식

HRID 1189640 반응식
[F:1][C:2]([F:9])([F:8])[CH:3]1[CH2:7][CH2:6][NH:5][CH2:4]1.Cl.CCN(C(C)C)C(C)C.[F:20][C:21]([F:44])([F:43])[C@H:22]1[CH2:27][CH2:26][C@H:25]([NH:28][C:29](=[O:42])[C:30]2[CH:35]=[C:34]([N+:36]([O-:38])=[O:37])[C:33]([NH:39][CH3:40])=[CH:32][C:31]=2F)[CH2:24][CH2:23]1>O.CC#N>[F:20][C:21]([F:43])([F:44])[C@H:22]1[CH2:27][CH2:26][C@H:25]([NH:28][C:29](=[O:42])[C:30]2[CH:35]=[C:34]([N+:36]([O-:38])=[O:37])[C:33]([NH:39][CH3:40])=[CH:32][C:31]=2[N:5]2[CH2:6][CH2:7][CH:3]([C:2]([F:9])([F:8])[F:1])[CH2:4]2)[CH2:24][CH2:23]1

참가 물질

7

반응물 4

HCID 313Hydrochloric AcidHCID 81531DiisopropylethylamineHCID 51521593-(Trifluoromethyl)pyrrolidineHCID 178482229HCID 178482229, 화합물

생성물 1

HCID 178482234HCID 178482234, 화합물

시약·촉매·용매 2

HCID 962Water용매HCID 6342Acetonitrile용매

실험 절차

A mixture of 3-trifluoromethyl-pyrrolidine×HCl (53 mg, 0.30 mmol), DIPEA (0.40 ml, 2.4 mmol), N-(trans-4-trifluoromethyl-cyclohexyl)-2-fluoro-4-methylamino-5-nitro-benzoic acid amide (100 mg, 0.28 mmol) and MeCN (2 mL) is stirred for 4.5 h at reflux. Then the mixture is diluted with water and the formed precipitate is filtered, washed with water and dried

후처리

  1. temperatureat reflux
  2. filtrationthe formed precipitate is filtered
  3. washwashed with water
  4. customdried

출처 및 근거

ORD 기록
ord-6ebbb829a94b4f8086bb4cb2742af89e
출처 데이터셋
uspto-grants-2014_03
특허 번호
US08674113B2

연결된 노트

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