Cesium carbonate → 6-[(6-tert-butylthiomethyl-pyridin-3-ylmethyl)-amino]-7-chloro-3-(2,2,2-trifluoroacetyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepine

반응식

[NH2:1][CH2:2][C:3]1[CH:4]=[N:5][C:6]([CH2:9][S:10][C:11]([CH3:14])([CH3:13])[CH3:12])=[CH:7][CH:8]=1.[Cl:15][C:16]1[CH:32]=[CH:31][C:19]2[CH2:20][CH2:21][N:22]([C:25](=[O:30])[C:26]([F:29])([F:28])[F:27])[CH2:23][CH2:24][C:18]=2[C:17]=1OS(C(F)(F)F)(=O)=O.C1C=CC(P(C2C(C3C(P(C4C=CC=CC=4)C4C=CC=CC=4)=CC=C4C=3C=CC=C4)=C3C(C=CC=C3)=CC=2)C2C=CC=CC=2)=CC=1.C(=O)([O-])[O-].[Cs+].[Cs+]>C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.[Pd].[Pd].C([O-])(=O)C.[Pd+2].C([O-])(=O)C.C1(C)C=CC=CC=1>[C:11]([S:10][CH2:9][C:6]1[N:5]=[CH:4][C:3]([CH2:2][NH:1][C:17]2[C:18]3[CH2:24][CH2:23][N:22]([C:25](=[O:30])[C:26]([F:28])([F:27])[F:29])[CH2:21][CH2:20][C:19]=3[CH:31]=[CH:32][C:16]=2[Cl:15])=[CH:8][CH:7]=1)([CH3:14])([CH3:13])[CH3:12]