Methyl iodide → HCID 21270736, 화합물

HRID 1193917노트

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HRID 1193917 반응식
[CH2:1]([O:3][C:4]1[N:5]([C:15]2[CH:20]=[C:19]([OH:21])[C:18]([Br:22])=[CH:17][C:16]=2[F:23])[C:6](=[O:14])[CH:7]=[C:8]([C:10]([F:13])([F:12])[F:11])[N:9]=1)[CH3:2].[CH3:24]I.[H-].[Na+]>CN(C)C=O>[CH2:1]([O:3][C:4]1[N:5]([C:15]2[CH:20]=[C:19]([O:21][CH3:24])[C:18]([Br:22])=[CH:17][C:16]=2[F:23])[C:6](=[O:14])[CH:7]=[C:8]([C:10]([F:13])([F:11])[F:12])[N:9]=1)[CH3:2]

참가 물질

5

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HCID 6328Methyl iodideHCID 24758Sodium hydrideHCID 212707472-ethoxy-1-(4-bromo-2-fluoro-5-hydroxyphenyl)-4-trifluoromethyl-6(1H)-pyrimidinone

생성물 1

HCID 21270736HCID 21270736, 화합물

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

using 2-ethoxy-1-(4-bromo-2-fluoro-5-hydroxyphenyl)-4-trifluoromethyl-6(1H)-pyrimidinone and methyl iodide with sodium hydride in dimethylformamide there is obtained 2-ethoxy-1-(4-bromo-2-fluoro-5-methoxyphenyl)-4-trifluoromethyl-6(1H)-pyrimidinone, m.p. 126°-128° C.

출처 및 근거

ORD 기록
ord-f65cf0ad08bf4f7d93833c34e18016bf
출처 데이터셋
uspto-grants-1989_03
특허 번호
US04812164

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