Hydrochloric Acid → HCID 11732720, 화합물

HRID 1194892노트

반응식

HRID 1194892 반응식
Cl.[OH:2]/[N:3]=[C:4](/[C:10]1[N:11]=[C:12]([NH:15][C:16]([C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[S:13][CH:14]=1)\[C:5]([O:7]CC)=[O:6].[OH-].[Na+].O.Cl>O1CCOCC1>[OH:2]/[N:3]=[C:4](/[C:10]1[N:11]=[C:12]([NH:15][C:16]([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)([C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=2)[C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)[S:13][CH:14]=1)\[C:5]([OH:7])=[O:6]

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 14798Sodium HydroxideHCID 9589415(Z)-Ethyl 2-(hydroxyimino)-2-(2-(tritylamino)thiazol-4-yl)acetate hydrochloride

생성물 1

HCID 11732720HCID 11732720, 화합물수율 96.6%

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

Ethyl (Z)-2-hydroxyimino-2-(2-tritylaminothiazol-4-yl)acetate hydrochloride (5 g) as a suspension in dioxane (50ml) was treated at room temperature with 1M aqueous sodium hydroxide (23 ml). After stirring for 12 h, water (50 ml) was added. The pH was adjusted to 1-2 with dilute hydrochloric acid. The resulting precipitate was filtered off, washed with water and dried over P2O5 to give the title compound (4.2 g) as a white solid; δH ((CD3)2SO) 6.73 (1H, s), 7.30 (15H, s).

후처리

  1. filtrationThe resulting precipitate was filtered off
  2. washwashed with water
  3. dry with materialdried over P2O5

출처 및 근거

ORD 기록
ord-5f2ee8dcb68d4ee586eb30b4b0ac683e
출처 데이터셋
uspto-grants-1989_03
특허 번호
US04816452

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