Trifluoroacetic acid → HCID 14368703, 화합물

반응식

[C:1]1([C:7](C2C=CC=CC=2)(C2C=CC=CC=2)O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.FC(F)(F)C(O[C:26](=O)[C:27]([F:30])(F)F)=O.[F:34][C:35](F)(F)[C:36](O)=O>>[F:30][C:27]1[CH:26]=[C:35]([F:34])[CH:36]=[C:6]2[C:5]=1[CH:4]=[CH:3][CH:2]=[C:1]2[CH3:7]

참가 물질

반응물 3

HCID 6422Trifluoroacetic acid

HCID 6457Triphenylcarbinol

HCID 9845Trifluoroacetic anhydride

생성물 1

HCID 14368703HCID 14368703, 화합물

실험 절차

2.5 g of 5,7-Difluoro-1-methyl-tetralol, 3.6 g of triphenylmethanol and 2.6 g of trifluoroacetic acid anhydride are refluxed for 5 hours in 16 ml of trifluoroacetic acid. The mixture is poured onto ice-water and extracted with dichloromethane. The organic phase is washed neutral with sodium bicarbonate solution, dried and concentrated. The oily crude product can be purified by chromatography over silica gel (eluant:hexane).

후처리

additionThe mixture is poured onto ice-water
extractionextracted with dichloromethane
washThe organic phase is washed neutral with sodium bicarbonate solution
customdried
concentrationconcentrated
customThe oily crude product can be purified by chromatography over silica gel (eluant:hexane)

출처 및 근거

ORD 기록: ord-ad67fd31fe2446d6979950a44886008f
출처 데이터셋: uspto-grants-1992_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05112851

반응 노트

불러오는 중…