1-Octanol → 2-Octyl glyceryl ether

HRID 1197383노트

반응식

HRID 1197383 반응식
S(=O)(=O)(O)O.[CH2:6]1[O:8][CH:7]1[CH2:9][OH:10].[OH-].[Na+].[CH2:13]([OH:21])[CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH3:20]>>[CH2:13]([O:21][CH:7]([CH2:9][OH:10])[CH2:6][OH:8])[CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH3:20]

참가 물질

5

반응물 4

HCID 9571-OctanolHCID 1118Sulfuric AcidHCID 11164GlycidolHCID 14798Sodium Hydroxide

생성물 1

HCID 3724412-Octyl glyceryl ether수율 15.9%

실험 절차

0.6 ml of concentrated sulfuric acid was added to 165 g of 1-octanol, the mixture was stirred at room temperature and 23.5 g of glycidol was added dropwise. The reaction mixture was poured on ice water, the mixture was neutralized with 1N aqueous sodium hydroxide solution and extracted with ether, and the ether layer was dried over anhydrous sodium sulfate. The solvent was distilled away, the most part of 1-octanol was removed by vacuum distillation, and the residue was distilled under a vacuum of 1 mmHg to give 10.3 g of the desired product containing a by-product 3-octyloxy-1,2-propanediol.

후처리

  1. additionThe reaction mixture was poured on ice water
  2. extractionextracted with ether
  3. dry with materialthe ether layer was dried over anhydrous sodium sulfate
  4. distillationThe solvent was distilled away
  5. customthe most part of 1-octanol was removed by vacuum distillation
  6. distillationthe residue was distilled under a vacuum of 1 mmHg

출처 및 근거

ORD 기록
ord-77d767bd16c94fefa353489b0b82a92f
출처 데이터셋
uspto-grants-1994_01
특허 번호
US05275757

반응 노트

불러오는 중…