Hydrazine hydrate (1:1) → 4-Phenoxybutan-1-amine

HRID 1198119

반응식

HRID 1198119 반응식
[O:1]([CH2:8][CH2:9][CH2:10][CH2:11][N:12]1C(=O)C2=CC=CC=C2C1=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.O.NN>C(O)C>[O:1]([CH2:8][CH2:9][CH2:10][CH2:11][NH2:12])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 24654Hydrazine hydrate (1:1)HCID 166375972-(4-Phenoxybutyl)-1H-isoindole-1,3(2H)-dione

생성물 1

HCID 1162404-Phenoxybutan-1-amine수율 96.2%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A mixture of N-(4-phenoxybutyl)phthalimide (7.8 g), hydrazine hydrate (7 ml) and ethanol (150 ml) was stirred for one hour under reflux. Crystalline precipitate was filtered off, then the filtrate was concentrated under reduced pressure to give 4-phenoxybutylamine (4.2 g, 95%) as an oily product.

후처리

  1. temperatureunder reflux
  2. filtrationCrystalline precipitate was filtered off
  3. concentrationthe filtrate was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-43de905befef4fd6a66a6a7f25f015a2
출처 데이터셋
uspto-grants-1994_01
특허 번호
US05280022

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