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Hydrochloric Acid → 6-Chloro-4,5-dihydro-4-methyl-5-oxo-imidazo(1,5-a)quinazoline-3-carboxylic acid

HRID 1199666
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반응식

HRID 1199666 반응식
[Cl:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[C:4](=[O:21])[N:5]([CH3:20])[C:6]1[N:7]2[CH:12]=[N:13][C:14]=1[C:15]([O:17]CC)=[O:16].O.[OH-].[Na+].Cl>C(O)C>[Cl:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[C:4](=[O:21])[N:5]([CH3:20])[C:6]1[N:7]2[CH:12]=[N:13][C:14]=1[C:15]([OH:17])=[O:16]
참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 14798Sodium HydroxideHCID 14460516Ethyl 4,5-dihydro-4-methyl-5-oxo-6-chloro-imidazo(1,5-a)quinazoline-3-carboxylate

생성물 1

HCID 144605626-Chloro-4,5-dihydro-4-methyl-5-oxo-imidazo(1,5-a)quinazoline-3-carboxylic acid수율 102.2%

시약·촉매·용매 1

HCID 702
Ethanol
용매

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온도
0 °C

실험 절차

Ethyl 6-chloro-4,5-dihydro-4-methyl-5-oxo-imidazo(1,5-a)-quinazoline-3-carboxylate (2.27 g,7.4 mmol) in a mixture of 50 ml of ethanol, 25 ml of water and 4.6 ml of 4M aqueous sodium hydroxide was refluxed for 1 h. Then the mixture was cooled to 0° C. and neutralized by addition of 4.6 ml of 4M hydrochloric acid. The precipitate was filtered off, rinsed with water and dried to give 2.1 g (100%) of 6-chloro-4,5-dihydro-4-methyl-5-oxo-imidazo(1.5-a)quinazoline-3-carboxylic acid.

후처리

  1. temperaturewas refluxed for 1 h
  2. filtrationThe precipitate was filtered off
  3. washrinsed with water
  4. customdried

출처 및 근거

ORD 기록
ord-c7e6c9133d0a4d7db9536178fd5751cf
출처 데이터셋
uspto-grants-1990_02
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US04902686

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