Acetic Anhydride → Ethyl 2-(2,4-dichloro-5-fluoro-3-nitrobenzoyl)-3-ethoxyacrylate

HRID 1199752

반응식

HRID 1199752 반응식
[Cl:1][C:2]1[C:15]([N+:16]([O-:18])=[O:17])=[C:14]([Cl:19])[C:13]([F:20])=[CH:12][C:3]=1[C:4]([CH2:6][C:7]([O:9][CH2:10][CH3:11])=[O:8])=[O:5].[CH:21](OCC)(OCC)[O:22][CH2:23][CH3:24].C(OC(=O)C)(=O)C>>[Cl:1][C:2]1[C:15]([N+:16]([O-:18])=[O:17])=[C:14]([Cl:19])[C:13]([F:20])=[CH:12][C:3]=1[C:4]([C:6](=[CH:21][O:22][CH2:23][CH3:24])[C:7]([O:9][CH2:10][CH3:11])=[O:8])=[O:5]

참가 물질

4

반응물 3

HCID 7918Acetic AnhydrideHCID 31214Ethyl orthoformateHCID 13733140Ethyl 2,4-dichloro-5-fluoro-3-nitro-beta-oxobenzenepropanoate

생성물 1

HCID 53944414Ethyl 2-(2,4-dichloro-5-fluoro-3-nitrobenzoyl)-3-ethoxyacrylate

실험 절차

244.8 g of ethyl (2,4-dichloro-5-fluoro-3-nitro-benzoyl)-acetate are heated at 150°-160° C. with 166 g of triethyl orthoformate and 185 g of acetic anhydride for 3 hours. The mixture is then concentrated in vacuo and 270 g of ethyl benzoyl-ethoxy-acrylate are obtained as an oily residue.

후처리

  1. concentrationThe mixture is then concentrated in vacuo and 270 g of ethyl benzoyl-ethoxy-acrylate
  2. customare obtained as an oily residue

출처 및 근거

ORD 기록
ord-47e1e26c466d426f9f565d6c3c3223cc
출처 데이터셋
uspto-grants-1990_02
특허 번호
US04902795

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