alpha-Hydroxytriazolam → 8-chloro-1-(hydroxymethyl)-6-(o-chlorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine acetate

HRID 1199788

반응식

HRID 1199788 반응식
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]3[C:12]([CH2:15][OH:16])=[N:13][N:14]=[C:10]3[CH2:9][N:8]=[C:7]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=3[Cl:23])[C:6]=2[CH:24]=1.[C:25]([O:28]C(=O)C)(=[O:27])[CH3:26]>O>[C:25]([OH:28])(=[O:27])[CH3:26].[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]3[C:12]([CH2:15][OH:16])=[N:13][N:14]=[C:10]3[CH2:9][N:8]=[C:7]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=3[Cl:23])[C:6]=2[CH:24]=1

참가 물질

4

반응물 2

HCID 1963alpha-HydroxytriazolamHCID 7918Acetic Anhydride

생성물 1

HCID 703594408-chloro-1-(hydroxymethyl)-6-(o-chlorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine acetate

시약·촉매·용매 1

HCID 962Water용매

실험 절차

In a manner similar to Example 12, a mixture of 8-chloro-1-(hydroxymethyl)-6-(o-chlorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine and acetic anhydride was heated on the water bath to give 8-chloro-1-(hydroxymethyl)-6-(o-chlorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine acetate (ester).

출처 및 근거

ORD 기록
ord-56f90f3cd8f44867a19c25169971f8bd
출처 데이터셋
uspto-grants-1990_02
특허 번호
US04902794

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