Propargyl alcohol → N-Boc-beta-alanine Propargyl Ester

HRID 12006

반응식

HRID 12006 반응식
[C:1]([NH:8][CH2:9][CH2:10][C:11]([OH:13])=[O:12])([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2].[CH2:14](O)[C:15]#[CH:16].C1(N=C=NC2CCCCC2)CCCCC1>CCOC(C)=O>[CH2:16]([O:12][C:11](=[O:13])[CH2:10][CH2:9][NH:8][C:1]([O:3][C:4]([CH3:6])([CH3:7])[CH3:5])=[O:2])[C:15]#[CH:14]

참가 물질

5

반응물 3

HCID 7859Propargyl alcoholHCID 10868DicyclohexylcarbodiimideHCID 76809N-((1,1-dimethylethoxy)carbonyl)-beta-alanine

생성물 1

HCID 11831152N-Boc-beta-alanine Propargyl Ester

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

N-Boc-β-alanine (1.91 g, 10.1 mmol) and propargyl alcohol (0.675 g, 12 mmol) were dissolved in EtOAc (25 mL). Dicyclohexyl-carbodiimide (DCC, 2.06 g, 10 mmol) was added to the solution and after 16 h of stirring at room temperature, the reaction mixture was filtered and evaporated to dryness under vacuum. Crude product yield

후처리

  1. filtrationthe reaction mixture was filtered
  2. customevaporated to dryness under vacuum
  3. customCrude product yield

출처 및 근거

ORD 기록
ord-71ffcbba883a4093b8e3933b35c16e12
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07727713B2

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