Sodium Hydroxide → HCID 178446994, 화합물

HRID 12066

반응식

HRID 12066 반응식
C(N(C(C)C)CC)(C)C.[C:10](Cl)(=[O:15])[CH2:11][CH2:12][CH2:13][CH3:14].Cl.Cl.[N:19]1[C:27]2[CH2:26][CH2:25][NH:24][CH2:23][C:22]=2[S:21][C:20]=1[NH:28][C:29]([NH2:31])=[NH:30].[OH-].[Na+]>CN(C)C=O.C(OCC)(=O)C>[C:10]([CH:23]1[C:22]2[S:21][C:20]([NH:28][C:29]([NH2:31])=[NH:30])=[N:19][C:27]=2[CH2:26][CH2:25][NH:24]1)(=[O:15])[CH2:11][CH2:12][CH2:13][CH3:14]

참가 물질

7

반응물 4

HCID 14798Sodium HydroxideHCID 61186Valeryl chlorideHCID 81531DiisopropylethylamineHCID 178478794HCID 178478794, 화합물

생성물 1

HCID 178446994HCID 178446994, 화합물

시약·촉매·용매 2

HCID 6228Dimethylformamide용매HCID 8857Ethyl Acetate용매

실험 절차

Diisopropylethylamine (0.22 mmol) and then pentanoyl chloride (0.11 mmol) are added to a stirred suspension of N-(4,5,6,7-tetrahydro-thiazolo[5,4-c]pyridine-2-yl)-guanidine-dihydrochloride (0.1 mmol) in dimethylformamide (0.7 ml) and the reaction mixture is stirred for another 16 hours at room temperature. After the addition of 2M caustic soda solution (1 ml) extraction is carried out with ethyl acetate. The combined organic phases produce the pure title compound after drying over sodium sulphate and concentrating to dryness.

출처 및 근거

ORD 기록
ord-98496fd20a5141068171bd4a1a3cc0ec
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07727979B2

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