Acetone → 4-[(2-Chloro-6-methylpyrimidin-4-yl)oxy]-2,5-dimethylaniline

HRID 12087

반응식

HRID 12087 반응식
[NH2:1][C:2]1[C:7]([CH3:8])=[CH:6][C:5]([OH:9])=[C:4]([CH3:10])[CH:3]=1.[OH-].[Na+].[Cl:13][C:14]1[N:19]=[C:18](Cl)[CH:17]=[CH:16][N:15]=1.[CH3:21]C(C)=O>O>[Cl:13][C:14]1[N:15]=[C:16]([O:9][C:5]2[C:4]([CH3:10])=[CH:3][C:2]([NH2:1])=[C:7]([CH3:8])[CH:6]=2)[CH:17]=[C:18]([CH3:21])[N:19]=1

참가 물질

6

반응물 4

HCID 180AcetoneHCID 14798Sodium HydroxideHCID 765444-Amino-2,5-dimethylphenolHCID 775312,4-Dichloropyrimidine

생성물 1

HCID 866289754-[(2-Chloro-6-methylpyrimidin-4-yl)oxy]-2,5-dimethylaniline

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A solution of 4.53 g (33 mmol) 4-amino-2,5-dimethylphenol and 1.44 g NaOH (2M) in 30 ml water were added dropwise to a solution of 4.89 g (30.0 mmol) of 2,4-dichloropyrimidine in 50 ml of acetone. The reaction mixture was stirred for 20 h at ambient temperature.

출처 및 근거

ORD 기록
ord-a317305e306944ef82b1ad5a3fc53986
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07727986B2

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