Triphenylphosphine → 4-Fluorophenethyltriphenylphosphonium bromide

HRID 12369

반응식

HRID 12369 반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][Br:10])=[CH:4][CH:3]=1.[C:11]1([P:17]([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>C1(C)C=CC=CC=1>[Br-:10].[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][P+:17]([C:18]2[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=2)([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=2)=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 11776TriphenylphosphineHCID 5731534-Fluorophenethyl bromide

생성물 1

HCID 223867454-Fluorophenethyltriphenylphosphonium bromide

시약·촉매·용매 1

HCID 1140Toluene용매

반응 조건

온도
200 °C

실험 절차

4-Fluorophenylethyl bromide (700 mg, 3.44 mmol) was dissolved in toluene (4 mL), triphenylphosphine (904 mg, 3.44 mmol) added and the solution heated for 10 min in a sealed flask at 200° C. under microwave heating. After cooling to rt, the solvent was decanted and the title compound was obtained quantitatively as the remaining glassy solid, which was used without further purification.

후처리

  1. temperatureheating
  2. temperatureAfter cooling to rt
  3. customthe solvent was decanted

출처 및 근거

ORD 기록
ord-ced818104f6646a0b4c67d321a5aa17e
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07727999B2

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