Acetic Anhydride → 1-Acetylindolin-2-one

HRID 12385

반응식

HRID 12385 반응식
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][C:2]1=[O:10].[C:11](OC(=O)C)(=[O:13])[CH3:12]>>[C:11]([N:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][C:2]1=[O:10])(=[O:13])[CH3:12]

참가 물질

3

반응물 2

HCID 7918Acetic AnhydrideHCID 321710Oxindole

생성물 1

HCID 3237191-Acetylindolin-2-one수율 93.7%

실험 절차

Indoline-2-one (6.65 g, 50 mmol) and acetic anhydride (9 mL) were heated at reflux for 15 h. After cooling, the product was filtered and rinsed with Et2O to give 2a as solids after vacuum drying (8.2 g, yield: 93.7 %).

후처리

  1. temperatureat reflux for 15 h
  2. temperatureAfter cooling
  3. filtrationthe product was filtered
  4. washrinsed with Et2O

출처 및 근거

ORD 기록
ord-a7734ec7f6ab472a91dc21117afbdc06
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07728008B2

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