Sodium Hydroxide → 5-Phenyl-1,2-oxazol-3-amine

HRID 1241596노트

반응식

HRID 1241596 반응식
[C:1]1([C:7]#[C:8][C:9]#[N:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl.[NH2:12][OH:13].[OH-].[Na+]>CCO.O>[NH2:10][C:9]1[CH:8]=[C:7]([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)[O:13][N:12]=1

참가 물질

6

반응물 3

HCID 14798Sodium HydroxideHCID 963823-Phenyl-2-propynenitrileHCID 443297Hydroxyamine hydrochloride

생성물 1

HCID 36207925-Phenyl-1,2-oxazol-3-amine

시약·촉매·용매 2

HCID 702Ethanol용매HCID 962Water용매

실험 절차

To a stirred solution of 3-phenyl-2-propyne-nitrile (1.27 g, 0.01 mol, Step A) in EtOH (20 mL) was added at RT hydroxylamine hydrochloride (3.5 g, 0.05 mol) followed by 10% NaOH (28 mL). The exothermic reaction was stirred at RT 24 h, then diluted with H2O. The resulting precipitate was filtered off, washed with H2O and dried over P2O5 to afford 3-amino-5-phenylisoxazole as a white crystalline solid.

후처리

  1. customThe exothermic reaction
  2. filtrationThe resulting precipitate was filtered off
  3. washwashed with H2O
  4. dry with materialdried over P2O5

출처 및 근거

ORD 기록
ord-2e390789c1c84e09a7cf468793ca3451
출처 데이터셋
uspto-grants-2006_10
특허 번호
US07115617B2

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