1-Butanol → HCID 21933852, 화합물

HRID 1241865노트

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HRID 1241865 반응식
[CH2:1]([OH:5])[CH2:2][CH2:3][CH3:4].C[Si]([N-][Si](C)(C)C)(C)C.[Na+].[F:16][C:17]1[CH:18]=[C:19]([N:24]2[C:29](=[O:30])[C:28](Cl)=[C:27]([Cl:32])[CH:26]=[N:25]2)[CH:20]=[CH:21][C:22]=1[F:23]>C1COCC1>[F:16][C:17]1[CH:18]=[C:19]([N:24]2[C:29](=[O:30])[C:28]([O:5][CH2:1][CH2:2][CH2:3][CH3:4])=[C:27]([Cl:32])[CH:26]=[N:25]2)[CH:20]=[CH:21][C:22]=1[F:23]

참가 물질

5

반응물 3

HCID 2631-ButanolHCID 2724254Sodium bis(trimethylsilyl)amideHCID 219343084,5-Dichloro-2-(3,4-difluorophenyl)pyridazin-3(2H)-one

생성물 1

HCID 21933852HCID 21933852, 화합물수율 79.4%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매3회

실험 절차

To a stirred, room temperature solution of n-butanol (0.81 g, 10.93 mmol, 1.1 equiv.) in THF (20 mL) was slowly added 1.0 M sodium bis(trimethylsilyl)amide in THF (12 mL, 12 mmol, 1.2 equiv.). The reaction mixture was stirred for 0.5 hours, then it was transferred to a solution of 2-(3,4-difluorophenyl)-4,5-dichloro-3(2H)-pyridazinone (2.88 g, 10.4 mmol, 1.0 equiv.) in THF (80 mL). The resulting reaction mixture was stirred for 0.5 hours at room temperature to provide the title compound (2.5 g, 79.4%).

후처리

  1. customThe resulting reaction mixture
  2. stirringwas stirred for 0.5 hours at room temperature

출처 및 근거

ORD 기록
ord-2bb0013ebc494688ab505e8554937010
출처 데이터셋
uspto-grants-2006_10
특허 번호
US07115591B2

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