Hydrochloric Acid → 2-(5-Chloro-2-phenyl-1-benzothiophen-3-yl)-1-ethanamine Hydrochloride

HRID 1242682노트

반응식

HRID 1242682 반응식
B#B.[Cl:3][C:4]1[CH:5]=[CH:6][C:7]2[S:11][C:10]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)=[C:9]([CH2:18][C:19]#[N:20])[C:8]=2[CH:21]=1.Cl>O1CCCC1>[ClH:3].[Cl:3][C:4]1[CH:5]=[CH:6][C:7]2[S:11][C:10]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)=[C:9]([CH2:18][CH2:19][NH2:20])[C:8]=2[CH:21]=1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 6328200DiboronHCID 219172462-(5-Chloro-2-phenyl-1-benzothiophen-3-yl)acetonitrile

생성물 1

HCID 124121842-(5-Chloro-2-phenyl-1-benzothiophen-3-yl)-1-ethanamine Hydrochloride

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

3 eq. of diborane in tetrahydrofuran and 1 eq. of the nitrile obtained in Step D are introduced into a 100 ml round-bottomed flask, and the mixture is then heated at reflux for 2 hours. After cooling, 15 eq. of 6M HCl are added and the tetrahydrofuran is evaporated off under reduced pressure. The precipitate formed is filtered off and recrystallised.

후처리

  1. temperaturethe mixture is then heated
  2. temperatureat reflux for 2 hours
  3. temperatureAfter cooling
  4. customthe tetrahydrofuran is evaporated off under reduced pressure
  5. customThe precipitate formed
  6. filtrationis filtered off
  7. customrecrystallised

출처 및 근거

ORD 기록
ord-ea530fb2e04645bdaa460681da639b7a
출처 데이터셋
uspto-grants-2006_10
특허 번호
US07115752B2

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