Iodoethane → tert-butyl N-ethyl-N-(prop-2-yn-1-yl)carbamate
반응식
[CH2:1]([NH:4][C:5](=[O:11])[O:6][C:7]([CH3:10])([CH3:9])[CH3:8])[C:2]#[CH:3].[H-].[Na+].[CH2:14](I)[CH3:15]>CN1CCCC1=O>[CH2:14]([N:4]([CH2:1][C:2]#[CH:3])[C:5](=[O:11])[O:6][C:7]([CH3:8])([CH3:10])[CH3:9])[CH3:15]참가 물질
5
실험 절차
The sub-titled compound was prepared from tert-butyl prop-2-ynylcarbamate (0.6g), 60% sodium hydride (0.186 g), ethyl iodide (1.55 ml) and anhydrous N-methyl-2-pyrrolidinone (4 ml) by the method of Example 2(ii). The crude product was purified by chromatography on silica gel eluting with iso-hexane:ethyl acetate (19:1) to afford (0.34 g) of a colourless oil.
후처리
- customThe crude product was purified by chromatography on silica gel eluting with iso-hexane:ethyl acetate (19:1)
출처 및 근거
- ORD 기록
- ord-5a3a9e4c2dc945ce9e5b489bb2fc660c
- 출처 데이터셋
- uspto-grants-2006_10
- 특허 번호
- US07129246B2
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