Hydrochloric Acid → 1H-Pyrazole-1-ethanol, 5-amino-4-nitroso-

HRID 1247787

반응식

HRID 1247787 반응식
[NH2:1][C:2]1[N:6]([CH2:7][CH2:8][OH:9])[N:5]=[CH:4][CH:3]=1.Cl.[N:11](OCCC(C)C)=[O:12]>C(O)C>[NH2:1][C:2]1[N:6]([CH2:7][CH2:8][OH:9])[N:5]=[CH:4][C:3]=1[N:11]=[O:12]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 8053Isoamyl NitriteHCID 3202812-(5-amino-1H-pyrazol-1-yl)ethan-1-ol

생성물 1

HCID 101490141H-Pyrazole-1-ethanol, 5-amino-4-nitroso-수율 51.3%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To a solution of 5-amino-1-(2-hydroxyethyl)pyrazole (6.35 g) in a mixed solvent of ethanol (25 ml) and concentrated hydrochloric acid (0.035 ml) was added dropwise isoamyl nitrite (7.03 g). The mixture was stirred at room temperature for 17 hours. The crystalline residue was collected by filtration and dried in vacuo to give 5-amino-1-(2-hydroxyethyl)-4-nitrosopyrazole (4.0 g) as a solid.

후처리

  1. filtrationThe crystalline residue was collected by filtration
  2. customdried in vacuo

출처 및 근거

ORD 기록
ord-caef93d0f1284e4084569b09d22d8d2d
출처 데이터셋
uspto-grants-2006_10
특허 번호
US07129232B2

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