Formamide → Hydrochloric Acid

HRID 1248128노트

반응식

HRID 1248128 반응식
C([NH:3][CH:4]([C:6]1([C:10]2[CH:15]=[CH:14][C:13]([Cl:16])=[C:12]([Cl:17])[CH:11]=2)[CH2:9][CH2:8][CH2:7]1)[CH3:5])=O.C(N)=O>>[ClH:16].[Cl:17][C:12]1[CH:11]=[C:10]([C:6]2([CH:4]([NH2:3])[CH3:5])[CH2:9][CH2:8][CH2:7]2)[CH:15]=[CH:14][C:13]=1[Cl:16]

참가 물질

4

반응물 2

HCID 713FormamideHCID 23292610N-formyl-1-[1-(3,4-dichlorophenyl)cyclobutyl]ethylamine

생성물 2

HCID 313Hydrochloric AcidHCID 130831401-[1-(3,4-Dichlorophenyl)cyclobutyl]ethylamine

실험 절차

The preparation of N-formyl-1-[1-(3,4-dichlorophenyl)cyclobutyl]ethylamine (m.p. 124°-125° C.) (Example 1(a) Formula I R1 =Me; R2 =H; R3 =H; R4 =CHO; R5 =4-Cl and R6 =3-Cl) described above was repeated and the product isolated by cooling the reaction mixture and collecting the solid produced by filtration. The formamide was then hydrolysed by concentrated hydrochloric acid in industrial methylated spirit to give the hydrochloride salt of 1-[1-(3,4-dichlorophenyl)cyclobutyl]ethylamine.

후처리

  1. customthe product isolated
  2. temperatureby cooling the reaction mixture
  3. customcollecting the solid
  4. customproduced by filtration

출처 및 근거

ORD 기록
ord-2ceaea4b9ae94efb952e64f263b58a0b
출처 데이터셋
uspto-grants-1985_06
특허 번호
US04522828

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