Sodium Hydroxide → N-(2-bromoethyl)-4-methoxy-2-nitrobenzamide

HRID 1248215

반응식

HRID 1248215 반응식
Br.[Br:2][CH2:3][CH2:4][NH2:5].[CH3:6][O:7][C:8]1[CH:16]=[CH:15][C:11]([C:12](Cl)=[O:13])=[C:10]([N+:17]([O-:19])=[O:18])[CH:9]=1.[OH-].[Na+]>O.C1C=CC=CC=1>[Br:2][CH2:3][CH2:4][NH:5][C:12](=[O:13])[C:11]1[CH:15]=[CH:16][C:8]([O:7][CH3:6])=[CH:9][C:10]=1[N+:17]([O-:19])=[O:18]

참가 물질

6

반응물 3

HCID 14798Sodium HydroxideHCID 27742172-Bromoethylamine hydrobromideHCID 214740534-Methoxy-2-nitrobenzoyl chloride

생성물 1

HCID 13476532N-(2-bromoethyl)-4-methoxy-2-nitrobenzamide수율 68%

시약·촉매·용매 2

HCID 241Benzene용매HCID 962Water용매2회

실험 절차

To a stirred and cooled (ice-bath) solution of 27.5 parts of 2-bromoethanamine hydrobromide in 200 parts of water is added a solution of 28.9 parts of 4-methoxy-2-nitrobenzoyl chloride in 63 parts of benzene at 5°-10° C. While stirring vigorously, there is added dropwise a solution of 10.8 parts of sodium hydroxide in 250 parts of water at 5°-10° C. Upon completion, stirring is continued for 2 hours at this temperature. The supernatant phase is decanted and the oily residue is stirred in 2-propanol. The product is filtered off and dried, yielding 27.5 parts (68%) of N-(2-bromoethyl)-4-methoxy-2-nitrobenzamide; mp. 133.8° C.

후처리

  1. stirringWhile stirring vigorously
  2. stirringUpon completion, stirring
  3. customThe supernatant phase is decanted
  4. stirringthe oily residue is stirred in 2-propanol
  5. filtrationThe product is filtered off
  6. customdried

출처 및 근거

ORD 기록
ord-82f0ddc216704c49ad26b788b03abb2f
출처 데이터셋
uspto-grants-1985_06
특허 번호
US04522945

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