Methyl iodide → HCID 86741155, 화합물

HRID 1249085노트

반응식

HRID 1249085 반응식
[CH2:1]([C@H:4]1[C:16]2[NH:15][C:14]3[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=3)[C:8]=2[CH2:7][C@H:6]([C:17]([OH:19])=[O:18])[NH:5]1)[CH2:2][CH3:3].C(N(CC)CC)C.[C:27](=[S:29])=[S:28].[CH3:30]I>C(O)C.CO>[CH2:1]([C@H:4]1[C:16]2[NH:15][C:14]3[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=3)[C:8]=2[CH2:7][C@H:6]([C:17]([OH:19])=[O:18])[N:5]1[C:27]([S:29][CH3:30])=[S:28])[CH2:2][CH3:3]

참가 물질

7

반응물 4

HCID 6328Methyl iodideHCID 6348Carbon DisulfideHCID 8471TriethylamineHCID 762192HCID 762192, 화합물

생성물 1

HCID 86741155HCID 86741155, 화합물수율 38.7%

시약·촉매·용매 2

HCID 702Ethanol용매HCID 887Methanol용매

실험 절차

In the same manner as described in Example 73, (1RS,3SR)-trans-1-n-propyl-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid (0.9 g), triethylamine (0.4 g), carbon disulfide (0.3 g), methyl iodide (0.56 g) and 80% methanol (14 ml) are reacted and treated. The product is treated with aqueous ethanol to give the title compound (0.47 g) as pale yellow powder.

후처리

  1. customare reacted
  2. additiontreated

출처 및 근거

ORD 기록
ord-18a3257665384a71a13b15fdb6f3c7dc
출처 데이터셋
uspto-grants-1986_12
특허 번호
US04628057

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