Hydrochloric Acid → Methyl 4-fluoro-3-oxopentanoate

온도

32.5 °C

To a liquid in which 1.31 g of a 62.8% sodium hydride had been suspended in 10 ml of tetrahydrofaran was added dropwise a mixed solution of 2.00 g of methyl 2-fluoropropionate and 2.10 g of methyl acetate over 10 minutes, and the mixture was then heated at 30 to 35° C. for 4 hours. After completion of the reaction, the reaction mixture was cooled to room temperature, neutralized with 1N-hydrochloric acid, and subjected to liquid separation. When the organic layer was quantitated by the gas chromatography internal standard method. As a result, it was found that 2.57 g of methyl 4-fluoro-3-oxopentanoate was formed (yield: 92%). When this organic layer was concentrated under reduced pressure and then distilled under reduced pressure, 2.03 g of methyl 4-fluoro-3-oxopentanoate could be obtained.

1. customAfter completion of the reaction
2. temperaturethe reaction mixture was cooled to room temperature
3. customsubjected to liquid separation
4. customwas formed (yield: 92%)
5. concentrationWhen this organic layer was concentrated under reduced pressure
6. distillationdistilled under reduced pressure, 2.03 g of methyl 4-fluoro-3-oxopentanoate
7. customcould be obtained

ORD 기록

ord-3ef10922e5d64660928af48f33324528

출처 데이터셋

uspto-grants-2002_01

DOI

10.6084/m9.figshare.5104873.v1

특허 번호

US06340757B1