Imidazole → HCID 53676658, 화합물

HRID 1251875

반응식

HRID 1251875 반응식
[OH:1][CH2:2][C:3]1[NH:4][CH:5]=[CH:6][N:7]=1.N1C=CN=C1.[Si:13](Cl)([C:26]([CH3:29])([CH3:28])[CH3:27])([C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1>CN(C=O)C>[Si:13]([O:1][CH2:2][C:3]1[NH:4][CH:5]=[CH:6][N:7]=1)([C:26]([CH3:29])([CH3:28])[CH3:27])([C:20]1[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=1)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

참가 물질

5

반응물 3

HCID 795ImidazoleHCID 94078tert-ButyldiphenylchlorosilaneHCID 5668301H-Imidazole-2-methanol

생성물 1

HCID 53676658HCID 53676658, 화합물수율 82%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

A solution of 2-hydroxymethylimidazole (1.96 g ; 0.02 mole), imidazole (3.4 g; 0.05 mole), tert-butyldiphenylsilyl chloride (6.6 g; 0.024 mole) in DMF (20 ml) was stirred under an argon atmosphere for 16 hours. The mixture was extracted with ethyl acetate and purified by flash column chromatography eluting with a gradient 50-70% ethyl acetate/petroleum ether to give 2-(tert-butyldiphenylsilyloxymethyl)imidazole as a solid.

후처리

  1. extractionThe mixture was extracted with ethyl acetate
  2. custompurified by flash column chromatography
  3. washeluting with a gradient 50-70% ethyl acetate/petroleum ether

출처 및 근거

ORD 기록
ord-629180fcd2854c04ab9ada2162252392
출처 데이터셋
uspto-grants-2002_01
특허 번호
US06342765B1

연결된 노트

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