Hydrogen Bromide → HCID 67207447, 화합물

HRID 1253539노트

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HRID 1253539 반응식
[Br:1][C:2]1[CH:3]=[C:4]([O:11]C)[C:5]2[N:6]([N:8]=[CH:9][CH:10]=2)[CH:7]=1.Br.[OH-].[Na+]>O.C(OCC)(=O)C>[Br:1][C:2]1[CH:3]=[C:4]([OH:11])[C:5]2[N:6]([N:8]=[CH:9][CH:10]=2)[CH:7]=1

참가 물질

6

반응물 3

HCID 260Hydrogen BromideHCID 14798Sodium HydroxideHCID 446228256-Bromo-4-methoxypyrazolo[1,5-a]pyridine

생성물 1

HCID 67207447HCID 67207447, 화합물

시약·촉매·용매 2

HCID 962Water용매HCID 8857Ethyl Acetate용매

반응 조건

온도
150 °C

실험 절차

6-bromo-4-methoxypyrazolo[1,5-a]pyridine (1.50 g, 6.61 mmol) was suspended in HBr (15 ml, 133 mmol). The reaction mixture was heated in the Biotage Initiator Series microwave for 80 minutes at 150° C. The reaction mixture was added dropwise via pipette to a mixture of NaOH (5.29 g, 132 mmol) in 50 mL of water and ice. The mixture was diluted in ethyl acetate, washed with saturated aqueous sodium bicarbonate and brine then dried over sodium sulfate, filtered and concentrated to give 6-bromopyrazolo[1,5-a]pyridin-4-ol.

후처리

  1. washwashed with saturated aqueous sodium bicarbonate and brine
  2. dry with materialthen dried over sodium sulfate
  3. filtrationfiltered
  4. concentrationconcentrated

출처 및 근거

ORD 기록
ord-f7583cc29d5647949bc680136988c357
출처 데이터셋
uspto-grants-2013_06
특허 번호
US08455477B2

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