N-bromobutanimide → Methyl 2-bromo-2-(2-fluorophenyl)acetate

HRID 1255090노트

반응식

HRID 1255090 반응식
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8][C:9]([O:11][CH3:12])=[O:10].[Br:13]N1C(=O)CCC1=O>C(Cl)(Cl)(Cl)Cl.C(Cl)Cl.Br>[CH3:12][O:11][C:9](=[O:10])[CH:8]([Br:13])[C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=1[F:1]

참가 물질

6

반응물 2

HCID 67184N-bromobutanimideHCID 2733230Methyl 2-fluorophenylacetate

생성물 1

HCID 18004644Methyl 2-bromo-2-(2-fluorophenyl)acetate수율 100%

시약·촉매·용매 3

HCID 260Hydrogen Bromide촉매HCID 5943Carbon Tetrachloride용매HCID 6344Dichloromethane용매

실험 절차

To a solution of methyl 2-(2-fluorophenyl)acetate (1.0 g, 5.95 mmol) in CCl4 (15 mL), are added N-bromo succinimide (1.06 g, 5.95 mmol) and 48% hydrogen bromide (33 uL, 0.30 mmol) and the reaction is refluxed for 15 hours. Reaction is diluted with DCM and washed with Na2CO3 and water. The organic phase is dried over Na2SO4, filtered and evaporated under vacuum to afford intermediate I261 as a dark brown oil (1.47 g, quantitative yield).

후처리

  1. temperaturethe reaction is refluxed for 15 hours
  2. customReaction
  3. washwashed with Na2CO3 and water
  4. dry with materialThe organic phase is dried over Na2SO4
  5. filtrationfiltered
  6. customevaporated under vacuum

출처 및 근거

ORD 기록
ord-00c0266630d54085bd1d4b1b7331e30b
출처 데이터셋
uspto-grants-2013_06
특허 번호
US08455646B2

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