3-Aminopropylphosphonic acid → 3-((6-Phenyl-5-(4-propylphenyl)pyridin-2-yl)methylamino)propylphosphonic Acid

HRID 12551

반응식

HRID 12551 반응식
[C:1]1([C:7]2[N:12]=[C:11]([CH:13]=O)[CH:10]=[CH:9][C:8]=2[C:15]2[CH:20]=[CH:19][C:18]([CH2:21][CH2:22][CH3:23])=[CH:17][CH:16]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH2:24][CH2:25][CH2:26][CH2:27][P:28](=[O:31])([OH:30])[OH:29].[BH3-]C#N.[Na+]>CO>[C:1]1([C:7]2[N:12]=[C:11]([CH2:13][NH:24][CH2:25][CH2:26][CH2:27][P:28](=[O:29])([OH:31])[OH:30])[CH:10]=[CH:9][C:8]=2[C:15]2[CH:20]=[CH:19][C:18]([CH2:21][CH2:22][CH3:23])=[CH:17][CH:16]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

참가 물질

5

반응물 3

HCID 975873-Aminopropylphosphonic acidHCID 5003444Sodium cyanoborohydrideHCID 866190756-Phenyl-5-(4-propylphenyl)pyridine-2-carbaldehyde2회

생성물 1

HCID 497872503-((6-Phenyl-5-(4-propylphenyl)pyridin-2-yl)methylamino)propylphosphonic Acid

시약·촉매·용매 1

HCID 887Methanol용매2회

실험 절차

Following General Procedure M, 6-phenyl-5-(4-propylphenyl)pyridine-2-carbaldehyde (Compound 59, 74 mg, 0.25 mmol), (3-amino-propyl)phosphonic acid (34 mg, 0.25 mmol), Bu4NOH (0.25 ml, 0.25 mmol, 1M in MeOH) and NaCNBH3 (15 mg, 0.25 mmol) in MeOH (5 ml) were reacted to produce the title compound as a white solid.

후처리

  1. customwere reacted

출처 및 근거

ORD 기록
ord-7379c5469345430caa35630f18548b1c
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07728014B2

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