Hydrochloric Acid → N-(5-bromo-4-methylthiazol-2-yl)-2,6-difluorobenzamide

HRID 1255115

반응식

HRID 1255115 반응식
[NH2:1][C:2]1[S:3][C:4]([Br:11])=[C:5]([C:7](F)(F)F)[N:6]=1.[F:12][C:13]1[CH:21]=[CH:20][CH:19]=[C:18]([F:22])[C:14]=1[C:15](Cl)=[O:16].Cl>C1COCC1.N1C=CC=CC=1>[Br:11][C:4]1[S:3][C:2]([NH:1][C:15](=[O:16])[C:14]2[C:13]([F:12])=[CH:21][CH:20]=[CH:19][C:18]=2[F:22])=[N:6][C:5]=1[CH3:7]

참가 물질

6

반응물 3

HCID 313Hydrochloric AcidHCID 874382,6-Difluorobenzoyl chlorideHCID 157107015-Bromo-4-(trifluoromethyl)-1,3-thiazol-2-amine

생성물 1

HCID 59004504N-(5-bromo-4-methylthiazol-2-yl)-2,6-difluorobenzamide수율 83%

시약·촉매·용매 2

HCID 1049Pyridine용매HCID 8028Tetrahydrofuran용매

실험 절차

2-Amino-5-bromo-4-trifluoromethylthiazole (0.8 g) was dissolved in 3 mL of 1:1 mixture of THF and pyridine. 2,6-difluorobenzoylchloride (0.6 g) was added at room temperature with stirring. The mixture was stirred for 3 hours at room temperature. The mixture was poured into ice water and acidified with aqueous hydrochloric acid then extracted with chloroform. The organic layer was dried over Na2SO4 and the solvent was removed under reduced pressure. Flash chromatography on silica gel gave the title compound as a white solid. Yield 83%.

후처리

  1. stirringThe mixture was stirred for 3 hours at room temperature
  2. extractionthen extracted with chloroform
  3. dry with materialThe organic layer was dried over Na2SO4
  4. customthe solvent was removed under reduced pressure

출처 및 근거

ORD 기록
ord-4b25ee29242644d2a6e5c548bebbf70c
출처 데이터셋
uspto-grants-2013_06
특허 번호
US08455658B2

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