Hydrochloric Acid → 2-(2,6-Difluorobenzamido)-5-(3-(trifluoromethyl)phenyl)thiazole-4-carboxylic acid

HRID 1255128노트

반응식

HRID 1255128 반응식
[F:1][C:2]1[CH:29]=[CH:28][CH:27]=[C:26]([F:30])[C:3]=1[C:4]([NH:6][C:7]1[S:8][C:9]([C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([C:22]([F:25])([F:24])[F:23])[CH:17]=2)=[C:10]([C:12]([O:14]C)=[O:13])[N:11]=1)=[O:5].[OH-].[Na+].Cl>CO>[F:30][C:26]1[CH:27]=[CH:28][CH:29]=[C:2]([F:1])[C:3]=1[C:4]([NH:6][C:7]1[S:8][C:9]([C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([C:22]([F:23])([F:24])[F:25])[CH:17]=2)=[C:10]([C:12]([OH:14])=[O:13])[N:11]=1)=[O:5]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 24765114Methyl 2-(2,6-difluorobenzamido)-5-(3-(trifluoromethyl)phenyl)thiazole-4-carboxylate

생성물 1

HCID 590044862-(2,6-Difluorobenzamido)-5-(3-(trifluoromethyl)phenyl)thiazole-4-carboxylic acid수율 95%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

Into a solution of Compound 35 (884 mg, 2 mmol) in 20 mL of MeOH was added NaOH (400 mg, 10 mmol). The solution was heated to reflux for 1 hour and cooled down to room temperature. The reaction was neutralized with 2N HCl and extracted with Et2O. The combined extracts were washed with water, dried (Na2SO4), filtered and concentrated. Recrystallization from Et2O gave Compound 66 (810 mg, 95%) as a white solid.

후처리

  1. temperatureThe solution was heated
  2. temperatureto reflux for 1 hour
  3. extractionextracted with Et2O
  4. washThe combined extracts were washed with water
  5. dry with materialdried (Na2SO4)
  6. filtrationfiltered
  7. concentrationconcentrated
  8. customRecrystallization from Et2O

출처 및 근거

ORD 기록
ord-fa1466a6875843c2b2096ea3a47d692d
출처 데이터셋
uspto-grants-2013_06
특허 번호
US08455658B2

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