Methyl iodide → 1-(5,6-Diphenyl-pyridin-2-yl)-propan-1-one O-Methyloxime

HRID 12561노트

반응식

HRID 12561 반응식
[C:1]1([C:7]2[CH:8]=[CH:9][C:10]([C:19](=[N:22][OH:23])[CH2:20][CH3:21])=[N:11][C:12]=2[C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[H-].[Na+].[CH3:26]I>C1COCC1>[CH3:26][O:23][N:22]=[C:19]([C:10]1[CH:9]=[CH:8][C:7]([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)=[C:12]([C:13]2[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=2)[N:11]=1)[CH2:20][CH3:21]

참가 물질

5

반응물 3

HCID 6328Methyl iodideHCID 24758Sodium hydrideHCID 1363323391-(5,6-Diphenyl-pyridin-2-yl)-propan-1-one Oxime2회

생성물 1

HCID 722584711-(5,6-Diphenyl-pyridin-2-yl)-propan-1-one O-Methyloxime

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

Following General Procedure Q, 1-(5,6-diphenyl-pyridin-2-yl)-propan-1-one oxime (Compound 81, 30 mg, 0.1 mmol), NaH (4.8 mg, 0.20 mmol) and MeI (140 mg, 0.99 mmol) in THF were reacted to obtain the title compound as an oil.

후처리

  1. customwere reacted

출처 및 근거

ORD 기록
ord-d523504399db40809f5e980e4e1ea47f
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07728014B2

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