Hydrochloric Acid → 5,6-Diphenyl-pyridine-2-carboxylic acid

HRID 12565

반응식

HRID 12565 반응식
[C:1]1([C:7]2[CH:8]=[CH:9][C:10]([C:19]([O:21]CC)=[O:20])=[N:11][C:12]=2[C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Li+].[OH-].Cl>CCO>[C:1]1([C:7]2[CH:8]=[CH:9][C:10]([C:19]([OH:21])=[O:20])=[N:11][C:12]=2[C:13]2[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 3939Lithium HydroxideHCID 14789610Ethyl 5,6-diphenylpyridine-2-carboxylate2회

생성물 1

HCID 214715265,6-Diphenyl-pyridine-2-carboxylic acid

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A solution of ethyl 5,6-diphenylpyridine-2-carboxylate (Compound 21, 40 mg, 0.13 mmol) and LiOH (1N, 1 ml) in EtOH (2 ml) was stirred at room temperature overnight. The mixture was acidified with 10% HCl, then extracted with EtOAc. The organic layer was washed with water, and brine, and dried over Na2SO4. The filtered solvent was concentrated in vacuo, and the residue was purified by silica gel chromatography (20-80% Ethyl acetate in hexane) to give title compound as a solid.

후처리

  1. extractionextracted with EtOAc
  2. washThe organic layer was washed with water, and brine
  3. dry with materialdried over Na2SO4
  4. concentrationThe filtered solvent was concentrated in vacuo
  5. customthe residue was purified by silica gel chromatography (20-80% Ethyl acetate in hexane)

출처 및 근거

ORD 기록
ord-43af859442634bd7bb2952e0d4381809
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07728014B2

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