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Hydrochloric Acid → 5-(trifluoromethyl)-1-({4-[3-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl}methyl)-1H-pyrazole-4-carboxylic acid

HRID 1257410
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HRID 1257410 반응식
[F:1][C:2]([F:30])([F:29])[C:3]1[N:7]([CH2:8][C:9]2[S:10][CH:11]=[C:12]([C:14]3[CH:19]=[CH:18][CH:17]=[C:16]([C:20]([F:23])([F:22])[F:21])[CH:15]=3)[N:13]=2)[N:6]=[CH:5][C:4]=1[C:24]([O:26]CC)=[O:25].[OH-].[Na+].C(O)C.Cl>O.C(OCC)(=O)C.O1CCCC1>[F:30][C:2]([F:1])([F:29])[C:3]1[N:7]([CH2:8][C:9]2[S:10][CH:11]=[C:12]([C:14]3[CH:19]=[CH:18][CH:17]=[C:16]([C:20]([F:23])([F:22])[F:21])[CH:15]=3)[N:13]=2)[N:6]=[CH:5][C:4]=1[C:24]([OH:26])=[O:25]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

8

반응물 4

HCID 313Hydrochloric AcidHCID 702EthanolHCID 14798Sodium HydroxideHCID 86650597ethyl 5-(trifluoromethyl)-1-({4-[3-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl}methyl)-1H-pyrazole-4-carboxylate

생성물 1

HCID 866505985-(trifluoromethyl)-1-({4-[3-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl}methyl)-1H-pyrazole-4-carboxylic acid수율 98.5%

시약·촉매·용매

3
HCID 962Water용매HCID 8028Tetrahydrofuran용매HCID 8857Ethyl Acetate용매

실험 절차

A mixture of the compound (0.13 g) obtained in Example 103d, 4N sodium hydroxide (1 mL), ethanol (2 mL) and tetrahydrofuran (0.5 mL) was stirred at room temperature for 20 hr. The reaction mixture was adjusted to pH 5 with 1N hydrochloric acid, and ethyl acetate and water were added. The ethyl acetate layer was separated, dried over sodium sulfate, and concentrated under reduced pressure to give the title compound (0.12 g) as colorless crystals.

후처리

  1. additionwere added
  2. customThe ethyl acetate layer was separated
  3. dry with materialdried over sodium sulfate
  4. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-ab95609c0d4a4112886b0f29930c2cf8
출처 데이터셋
uspto-grants-2013_06
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08461348B2

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