Hydrochloric Acid → HCID 66939369, 화합물

HRID 1257413노트

반응식

HRID 1257413 반응식
[F:1][C:2]1[C:7]([C:8]([F:11])([F:10])[F:9])=[CH:6][CH:5]=[CH:4][C:3]=1[C:12]1[O:13][CH:14]=[C:15]([CH2:17][N:18]2[CH:22]=[C:21]([C:23]([O:25]CC)=[O:24])[CH:20]=[N:19]2)[N:16]=1.[OH-].[Na+].C(O)C.Cl>O1CCCC1>[F:1][C:2]1[C:7]([C:8]([F:9])([F:10])[F:11])=[CH:6][CH:5]=[CH:4][C:3]=1[C:12]1[O:13][CH:14]=[C:15]([CH2:17][N:18]2[CH:22]=[C:21]([C:23]([OH:25])=[O:24])[CH:20]=[N:19]2)[N:16]=1

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 702EthanolHCID 14798Sodium HydroxideHCID 66939284HCID 66939284, 화합물

생성물 1

HCID 66939369HCID 66939369, 화합물수율 78.5%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

A mixture of the compound (0.44 g) obtained in Example 105b, 4N sodium hydroxide (3 mL), ethanol (8 mL) and tetrahydrofuran (2 mL) was stirred at room temperature for 16 hr. The reaction mixture was adjusted to pH 5 with 1N hydrochloric acid, and the precipitate was collected by filtration, dried under reduced pressure and recrystallized from ethanol-hexane to give the title compound (0.32 g) as colorless crystals.

후처리

  1. filtrationthe precipitate was collected by filtration
  2. customdried under reduced pressure
  3. customrecrystallized from ethanol-hexane

출처 및 근거

ORD 기록
ord-9fd40d7fff4648aa8b54e4489c064a35
출처 데이터셋
uspto-grants-2013_06
특허 번호
US08461348B2

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