Hydrochloric Acid → Pyridine, 2-(4-aminopyrazol-1-yl)-

HRID 1260333노트

반응식

HRID 1260333 반응식
C(OC(=O)[NH:7][C:8]1[CH:9]=[N:10][N:11]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][N:14]=2)[CH:12]=1)(C)(C)C.Cl.[OH-].[Na+]>O1CCOCC1>[N:14]1[CH:15]=[CH:16][CH:17]=[CH:18][C:13]=1[N:11]1[CH:12]=[C:8]([NH2:7])[CH:9]=[N:10]1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 67299900HCID 67299900, 화합물

생성물 1

HCID 206681Pyridine, 2-(4-aminopyrazol-1-yl)-수율 96%

시약·촉매·용매 1

HCID 312751,4-Dioxane용매2회

실험 절차

A solution of (1-pyridin-2-yl-1H-pyrazol-4-yl)-carbamic acid tert-butyl ester (185 mg, 0.72 mmol) in dioxane (1.85 ml) was treated with 4M HCl in dioxane (1.85 ml) and the resulting suspension was stirred at ambient temperature for 2 hours. The reaction mixture was adjusted to basic pH with sodium hydroxide (20 ml, 0.5M aqueous solution) and extracted with dichloromethane. The combined organic phases were dried and the solvent was evaporated to yield the product as light brown solid (110 mg, 96%) which was used without any further purification. MS: M=161.3 (M+H)+

후처리

  1. extractionextracted with dichloromethane
  2. customThe combined organic phases were dried
  3. customthe solvent was evaporated

출처 및 근거

ORD 기록
ord-9fd12c0b204e4bd3b2985134fb0f058c
출처 데이터셋
uspto-grants-2013_06
특허 번호
US08470820B2

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