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Hydrochloric Acid → alpha-[3-[4-(1,2-Benzisothiazol-3-yl)-1-piperazinyl]propyl]-4-fluorobenzenemethanol

HRID 1262551
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반응식

HRID 1262551 반응식
[BH4-].[Na+].Cl.[S:4]1[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=2[C:6]([N:13]2[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][CH2:21][C:22]([C:24]3[CH:29]=[CH:28][C:27]([F:30])=[CH:26][CH:25]=3)=[O:23])[CH2:15][CH2:14]2)=[N:5]1.Cl>C(O)C>[S:4]1[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=2[C:6]([N:13]2[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][CH2:21][CH:22]([C:24]3[CH:25]=[CH:26][C:27]([F:30])=[CH:28][CH:29]=3)[OH:23])[CH2:15][CH2:14]2)=[N:5]1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 4311764Sodium borohydrideHCID 132324854-[4-(1,2-Benzisothiazol-3-yl)-1-piperazinyl]-1-(4-fluorophenyl)-1-butanone hydrochloride

생성물 1

HCID 13232486alpha-[3-[4-(1,2-Benzisothiazol-3-yl)-1-piperazinyl]propyl]-4-fluorobenzenemethanol수율 69%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

Sodium borohydride (1.0 g., 0.026 mole) is added portionwise to a stirred suspension of 4-[4-(1,2-benzisothiazol-3-yl)-1-piperzinyl]-1-(4-fluorophenyl)-1-butanone hydrochloride (3.34 g., 0.008 mole) in 150 ml. of absolute ethanol. The mixture is stirred for a 20 hr. period, acidified with ethanolic hydrogen chloride, stirred for an additional 2 hr. period and concentrated in vacuo. Residual material is partitioned between chloroform and 1 N aqueous sodium hydroxide and the chloroform phase dried over magnesium sulfate and concentrated in vacuo to afford 2.31 g. (69% yield) of the title compound as the free base. The free base is converted to the hydrochloride in ethanol with ethanolic hydrogen chloride to afford α-[3-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]propyl]-4-fluorobenzenemethanol hydrochloride, m.p. 200°-202° C.

후처리

  1. stirringstirred for an additional 2 hr
  2. concentrationperiod and concentrated in vacuo
  3. customResidual material is partitioned between chloroform and 1 N aqueous sodium hydroxide
  4. dry with materialthe chloroform phase dried over magnesium sulfate
  5. concentrationconcentrated in vacuo
  6. customto afford 2.31 g

출처 및 근거

ORD 기록
ord-df2d392840404f5ea64bbf30229a5941
출처 데이터셋
uspto-grants-1984_06
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US04452799

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