Hydrochloric Acid → HCID 15114475, 화합물

HRID 126674노트

반응식

HRID 126674 반응식
O[CH:2]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)[CH2:3][CH2:4][NH:5][CH3:6].Cl.S(Cl)([Cl:16])=O>C(Cl)(Cl)Cl>[Cl:16][CH:2]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)[CH2:3][CH2:4][NH:5][CH3:6]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 24386Thionyl ChlorideHCID 27339893-Methylamino-1-phenylpropanol

생성물 1

HCID 15114475HCID 15114475, 화합물

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

To a cooled suspension of 20 g of γ-hydroxy-N-methylphenylpropylamine.HCl in chloroform are added dropwise 30 ml of thionylchloride. The mixture is subsequently stirred at room temperature till all solid substance has been dissolved. The solvent chloroform and the excess of thionylchloride are distilled off after which the residue is washed with ether and then made alkaline (pH=8) with a sodiumcarbonate solution (10%). The alkaline solution is subsequently extracted with ether and the ether extracts washed with water, dried and evaporated to dryness. The residue (oil) is used without any additional purification (yield 15.6 g; 85%).

후처리

  1. dissolutionhas been dissolved
  2. distillationThe solvent chloroform and the excess of thionylchloride are distilled off after which the residue
  3. washis washed with ether
  4. extractionThe alkaline solution is subsequently extracted with ether
  5. washthe ether extracts washed with water
  6. customdried
  7. customevaporated to dryness
  8. customThe residue (oil) is used without any additional purification (yield 15.6 g; 85%)

출처 및 근거

ORD 기록
ord-370890994df44bb58148c361ceeb5f62
출처 데이터셋
uspto-grants-1981_03
특허 번호
US04254031

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