Sodium Chlorate → HCID 68803290, 화합물

HRID 1270719노트

반응식

HRID 1270719 반응식
[CH2:1]1[CH2:6][CH2:5][CH:4]([CH2:7][C:8]([NH:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[O:9])[CH2:3][CH2:2]1.[Cl:17]([O-])(=O)=O.[Na+].S(=O)(O)[O-].[Na+]>Cl.C(O)(=O)C.O>[Cl:17][CH:2]1[CH2:3][CH:4]([CH2:7][C:8]([NH:10][C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=2)=[O:9])[CH2:5][CH2:6][CH2:1]1

참가 물질

7

반응물 3

HCID 516902Sodium ChlorateHCID 880922HCID 880922, 화합물HCID 23665763Sodium Bisulfite

생성물 1

HCID 68803290HCID 68803290, 화합물

시약·촉매·용매 3

HCID 176Acetic Acid용매HCID 313Hydrochloric Acid용매HCID 962Water용매2회

실험 절차

4-Cyclohexylacetanilide (24 g, 110 mmol) is dissolved in a mixture of concentrated HCl (25 mL) and acetic acid (75 mL). The mixture is cooled in an ice bath and a solution of sodium chlorate (NaClO3, 7.5 g, 70 mmol) in water (30 mL) is added via a dropping funnel. The reaction is allowed to warm to room temperature and then poured into saturated sodium bisulfite solution (500 mL). The solid which forms is isolated by filtration and subsequently washed first with water (500 mL) and then a mixture of hexanes/Et2O (10:1, 500 mL). The resulting solid is air dried to yield 2-chloro-4-cyclohexylacetanilide (m.p. 110–112° C.).

후처리

  1. temperatureThe mixture is cooled in an ice bath
  2. customdried

출처 및 근거

ORD 기록
ord-5799d97428b14d8faba4b4ac81245470
출처 데이터셋
uspto-grants-2007_04
특허 번호
US07202364B2

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