Hydrochloric Acid → 5-(2-fluoro-3-pyridinyl)-2,4(1H,3H)-pyrimidinedione hydrochloride

HRID 12713

반응식

HRID 12713 반응식
[F:1][C:2]1[C:7]([C:8]2[C:9]([O:16]C)=[N:10][C:11]([O:14]C)=[N:12][CH:13]=2)=[CH:6][CH:5]=[CH:4][N:3]=1.O1CCOCC1.[ClH:24]>>[ClH:24].[F:1][C:2]1[C:7]([C:8]2[C:9](=[O:16])[NH:10][C:11](=[O:14])[NH:12][CH:13]=2)=[CH:6][CH:5]=[CH:4][N:3]=1

참가 물질

4

반응물 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 589941555-(2-Fluoro-3-pyridinyl)-2,4-bis(methyloxy)pyrimidine

생성물 1

HCID 686945025-(2-fluoro-3-pyridinyl)-2,4(1H,3H)-pyrimidinedione hydrochloride

실험 절차

A solution of 5-(2-fluoro-3-pyridinyl)-2,4-bis(methyloxy)pyrimidine (Prep87, 2.8 g, 11.90 mmol) in HCl 4M in 1,4dioxane (42 mL, 168 mmol) was heated at 90° C. for 1 h. A white precipitate crashed out of the solution. Volatiles were evaporated under reduced pressure to give title compound, pale yellow solid (2.75 g).

후처리

  1. customVolatiles were evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-7dfa12c1ad044b53834cd890affd01db
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07727988B2

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