Sodium Hydroxide → HCID 69354532, 화합물

HRID 1271300노트

반응식

HRID 1271300 반응식
[C:1]([O:5][C:6](=[O:32])[CH2:7][O:8][CH2:9][CH2:10][CH2:11][CH2:12][S:13][C:14]1[CH:19]=[N:18][C:17]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)=[C:16]([C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)[N:15]=1)([CH3:4])([CH3:3])[CH3:2].ClC1C=C(C=CC=1)C(OO)=[O:38].[OH-].[Na+]>C(Cl)(Cl)Cl>[C:1]([O:5][C:6](=[O:32])[CH2:7][O:8][CH2:9][CH2:10][CH2:11][CH2:12][S:13]([C:14]1[CH:19]=[N:18][C:17]([C:20]2[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=2)=[C:16]([C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)[N:15]=1)=[O:38])([CH3:4])([CH3:2])[CH3:3]

참가 물질

5

반응물 3

HCID 14798Sodium HydroxideHCID 70297m-Chloroperbenzoic acidHCID 69354035HCID 69354035, 화합물

생성물 1

HCID 69354532HCID 69354532, 화합물수율 40%

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

While stirring under ice cooling, to a solution of 350 mg of 2-{4-[(5,6-diphenylpyrazin-2-yl)thio]butyloxy}acetic acid tert-butyl ester obtained in Example 34 in 5 ml of chloroform, 191 mg of 70% m-chloroperoxybenzoic acid was added, followed by stirring for 2 hours. The reaction solution was combined with 20 ml of a 0.2N sodium hydroxide solution, extracted with chloroform and dried over anhydrous magnesium sulfate, and then the solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography to obtain 145 mg of the desired compound as a pale yellow oily substance.

후처리

  1. additionwas added
  2. extractionextracted with chloroform
  3. dry with materialdried over anhydrous magnesium sulfate
  4. customthe solvent was evaporated under reduced pressure
  5. customThe residue was purified by silica gel column chromatography

출처 및 근거

ORD 기록
ord-b3a4bf068a5d4bf0b1a966eebe9e0157
출처 데이터셋
uspto-grants-2007_04
특허 번호
US07205302B2

반응 노트

불러오는 중…