1-Butanol → 2-chloro-N-(phenylmethyl)-9-(tetrahydro-3-thienyl)-9H-purin-6-amine

HRID 1272621노트

반응식

HRID 1272621 반응식
[Cl:1][C:2]1[N:10]=[C:9]2[C:5]([N:6]=[CH:7][N:8]2[CH:11]2[CH2:15][CH2:14][S:13][CH2:12]2)=[C:4](Cl)[N:3]=1.C(O)CCC.[CH2:22]([NH2:29])[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1>C(O)(C)C>[Cl:1][C:2]1[N:10]=[C:9]2[C:5]([N:6]=[CH:7][N:8]2[CH:11]2[CH2:15][CH2:14][S:13][CH2:12]2)=[C:4]([NH:29][CH2:22][C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[N:3]=1

참가 물질

5

반응물 3

HCID 2631-ButanolHCID 7504BenzylamineHCID 219229912,6-dichloro-9-(tetrahydro-3-thienyl)-9H-purine

생성물 1

HCID 219229482-chloro-N-(phenylmethyl)-9-(tetrahydro-3-thienyl)-9H-purin-6-amine

시약·촉매·용매 1

HCID 3776Isopropanol용매

반응 조건

온도
97.5 °C

실험 절차

120 mg of the product obtained in Stage 1 above, 2 ml of butanol and 0,105 ml of benzylamine are mixed together and the reaction medium is heated to a temperature of approximately 95 to 100° C. for 10 hours. It is then left to return to ambient temperature and diluted with 5 ml of isopropanol, followed by separating, washing with 5 ml of isopropanol and drying under vacuum at approximately 30° C. In this way 132 mg of expected product is obtained in the form of white crystals.

후처리

  1. waitIt is then left
  2. customto return to ambient temperature
  3. customby separating
  4. washwashing with 5 ml of isopropanol
  5. customdrying under vacuum at approximately 30° C

출처 및 근거

ORD 기록
ord-a8c3d49207da40e58f4aaf39669f9c0a
출처 데이터셋
uspto-grants-2007_04
특허 번호
US07208598B2

반응 노트

불러오는 중…