Hydrochloric Acid → HCID 12876160, 화합물

HRID 127293

반응식

HRID 127293 반응식
[SH:1][C:2]([CH3:13])([CH3:12])[C:3]([NH:5][C@H:6]([C:9]([OH:11])=[O:10])[CH2:7][SH:8])=[O:4].[C:14](Cl)(=[O:19])[C:15]([CH3:18])([CH3:17])[CH3:16].Cl>[OH-].[Na+]>[C:14]([S:8][CH2:7][C@@H:6]([C:9]([OH:11])=[O:10])[NH:5][C:3](=[O:4])[C:2]([S:1][C:14](=[O:19])[C:15]([CH3:18])([CH3:17])[CH3:16])([CH3:13])[CH3:12])(=[O:19])[C:15]([CH3:18])([CH3:17])[CH3:16]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 62493Pivaloyl chlorideHCID 656604Bucillamine

생성물 1

HCID 12876160HCID 12876160, 화합물수율 16.4%

시약·촉매·용매 1

HCID 14798Sodium Hydroxide용매2회

실험 절차

N-(2-Mercapto-2-methylpropanoyl)-L-cysteine (11.2 g, 0.05 mol) is dissolved in N sodium hydroxide (50 ml) and pivaloyl chloride (17.0 g, 0.13 mol) and aqueous N sodium hydroxide (150 ml) are added dropwise at 0° C. with stirring under a nitrogen atmosphere. After the addition, the mixture is stirred for 1 hour at room temperature and acidified with 6 N hydrochloric acid. The produced oil is extracted with ethyl acetate and the organic layer is washed with water, dried and concentrated to dryness under reduced pressure to yield 3.2 g (16.4%) of S-pivaloyl-N-(S-pivaloyl-2-mercapto-2-methylpropanoyl)-L-cysteine.

후처리

  1. additionare added dropwise at 0° C.
  2. additionAfter the addition
  3. stirringthe mixture is stirred for 1 hour at room temperature
  4. extractionThe produced oil is extracted with ethyl acetate
  5. washthe organic layer is washed with water
  6. customdried
  7. concentrationconcentrated to dryness under reduced pressure

출처 및 근거

ORD 기록
ord-7c4dd1599f7b4ac3a70bf509b882be75
출처 데이터셋
uspto-grants-1981_03
특허 번호
US04255446

연결된 노트

불러오는 중…