Hydrochloric Acid → HCID 12876158, 화합물

HRID 127294

반응식

HRID 127294 반응식
[SH:1][C:2]([CH3:13])([CH3:12])[C:3]([NH:5][C@H:6]([C:9]([OH:11])=[O:10])[CH2:7][SH:8])=[O:4].[C:14](Cl)(=[O:19])[C:15]([CH3:18])([CH3:17])[CH3:16].Cl>[OH-].[Na+]>[C:14]([S:8][CH2:7][C@@H:6]([C:9]([OH:11])=[O:10])[NH:5][C:3](=[O:4])[C:2]([SH:1])([CH3:13])[CH3:12])(=[O:19])[C:15]([CH3:18])([CH3:17])[CH3:16]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 62493Pivaloyl chlorideHCID 656604Bucillamine

생성물 1

HCID 12876158HCID 12876158, 화합물수율 75%

시약·촉매·용매 1

HCID 14798Sodium Hydroxide용매2회

반응 조건

온도
0 °C

실험 절차

N-(2-Mercapto-2-methylpropanoyl)-L-cysteine (11.2 g, 0.05 mol) is dissolved in N sodium hydroxide (50 ml) and then pivaloyl chloride (6.6 g, 0.055 mol) and N sodium hydroxide (60 ml) are added dropwise while stirring under a nitrogen atmosphere at 0° C. After the addition, the mixture is stirred for 1 hour at room temperature and acidified with 6 N hydrochloric acid. The produced oil is extracted with ethyl acetate. The organic layer is washed with water, dried and concentrated to dryness to yield 11.5 g (75.0%) S-pivaloyl-N-(2-mercapto-2-methylpropanoyl)-L-cysteine.

후처리

  1. additionAfter the addition
  2. stirringthe mixture is stirred for 1 hour at room temperature
  3. extractionThe produced oil is extracted with ethyl acetate
  4. washThe organic layer is washed with water
  5. customdried
  6. concentrationconcentrated to dryness

출처 및 근거

ORD 기록
ord-9f70f753115c4457a6e4c7a2c15df00b
출처 데이터셋
uspto-grants-1981_03
특허 번호
US04255446

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